Etofylline + Theophylline
Etofylline and Theophylline are xanthine derivatives. They work by relaxing the smooth muscles of the bronchial airways and pulmonary blood vessels, thereby reducing airway resistance and improving airflow. This combination is highly effective in managing chronic respiratory conditions but requires careful dosage monitoring due to a narrow therapeutic index.
Dosage by Body Weight
Adults usually take 1 tablet of immediate or prolonged-release form 1 to 3 times daily, preferably after meals to prevent gastric irritation. Dosage must be strictly individualized. Pediatric dosing must be carefully calculated by a physician based on the theophylline component and patient's clinical response.
- Body Weight
- Below 5 kg
- Dose
- Not routine / Highly restricted
- Frequency
- Use only if strictly prescribed by a pediatrician
- Tracking Notes
- High risk of toxicity in neonates and small infants due to immature hepatic metabolism.
- Body Weight
- 5-7 kg
- Dose
- Dose must be individualized
- Frequency
- Strictly under specialist guidance
- Tracking Notes
- Monitor closely for signs of toxicity like vomiting, irritability, and rapid heart rate.
- Body Weight
- 8-10 kg
- Dose
- 2.5 ml to 5 ml of pediatric syrup (containing Etofylline 23mg + Theophylline 7mg per ml)
- Frequency
- Every 8 to 12 hours
- Tracking Notes
- Dose is calculated based on active theophylline content (typically 4-5 mg/kg/dose).
- Body Weight
- 11-15 kg
- Dose
- 5 ml of pediatric syrup
- Frequency
- Every 8 to 12 hours
- Tracking Notes
- Ensure adequate hydration. Do not crush or chew solid formulations if prescribed.
- Body Weight
- 16-20 kg
- Dose
- 5 ml to 7.5 ml of pediatric syrup
- Frequency
- Every 8 to 12 hours
- Tracking Notes
- Adult formulations (tablets) should not be given to children in this weight bracket.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine / Highly restricted | Use only if strictly prescribed by a pediatrician | High risk of toxicity in neonates and small infants due to immature hepatic metabolism. |
| 5-7 kg | Dose must be individualized | Strictly under specialist guidance | Monitor closely for signs of toxicity like vomiting, irritability, and rapid heart rate. |
| 8-10 kg | 2.5 ml to 5 ml of pediatric syrup (containing Etofylline 23mg + Theophylline 7mg per ml) | Every 8 to 12 hours | Dose is calculated based on active theophylline content (typically 4-5 mg/kg/dose). |
| 11-15 kg | 5 ml of pediatric syrup | Every 8 to 12 hours | Ensure adequate hydration. Do not crush or chew solid formulations if prescribed. |
| 16-20 kg | 5 ml to 7.5 ml of pediatric syrup | Every 8 to 12 hours | Adult formulations (tablets) should not be given to children in this weight bracket. |
Formulation
Purpose
Used as a bronchodilator to relieve and prevent bronchospasm associated with asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD).
Generic Name
Etofylline + TheophyllineBranded Drug Names
Etofylline + Theophylline is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.